The role of Glucosamine for Dogs

 

The role of Glucosamine in healing and repair:
The benefit of Glucosamine in the treatment of osteoarthritis in dogs is well known but not so well known is the ability of Glucosamine to heal and repair wounds, promote faster healing following injury or surgery and possibly reduce scarring.

Glucosamine for dogs following surgery or trauma:
There is a great deal of scientific research that demonstrates that Glucosamine may have a vital role in helping dogs heal and repair faster. To understand how this works we need to look at nutrients and their role as building blocks in all body processes including healing and repair. Researchers are slowly revealing the fascinating complexity of nutrients connectivity. We are beginning to discover how each nutrient is linked to other nutrients and how the whole jig-saw of life fits together.

Is Glucosamine for dogs safe?
We need to be careful how we interpret many of the discoveries that are being revealed by research. When we look at the great web of life it is unwise to pick on a nutrient that seems to performs a certain role and assume that adding extra amounts of this nutrient to the diet must be a good thing: it may not. It might even cause imbalances in the system that will do more harm than good. There are a number of things we need to determine before we use an ingredient. Is it safe? Will it cause any imbalance? What is the clinically relevant dose, in other words how much do we give to our dog before it produces a benefit? Is there any side effects? Glucosamine meets all the criterion of this type of questioning. Glucosamine for dogs is safe for long term use.

Glucosamine for dogs: where it fits in the healing process.
When your dog is injured or has an operation a whole orchestra of instruments begins to play a healing melody. When the healing is to be conducted in the connective tissue the big players are fibroblasts and Hyaluronic acid and Glucosamine has a supportive and important role in the healing function.

Glucosamine for dogs: Hyaluronic acid synthesis.
When any part of the connective tissue is injured fibroblasts produce large amounts of Hyaluronic acid to activate healing and Glucosamine is one of the building blocks of Hyaluronic acid. Administration of Glucosamine can increase the production of Hyaluronic acid.2

Glucosamine for dogs improves healing: the science.

Studies have indicated that Glucosamine may be rate limiting for the body's Hyaluronic Acid synthesis and that the supplementation of Glucosamine following surgery or trauma may increase Hyaluronic acid production in the wound and encourage more rapid healing and diminish scarring.1

The role of Glucosamine: fibroblast and Hyaluronic acid

Fibroblasts, the most common cells found in the connective tissue of dogs play a major role in wound healing. During the early stages of wound healing fibroblasts rapidly increase the production of Hyaluronic acid and this is thought to be of major significance since Hyaluronic acid stimulates the mitosis and migration of mesenchymal and epithelial cells.

Our data suggest that exogenous GlcN can increase HA production by synovium tissue and is more effective at lower concentrations than Gluc. This might indicate that GlcN exerts its potential analgesic properties through stimulation of synovial HA production.